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Proteomic analysis of the frontal cortex (area 8) in C9orf72 FTD patients revealed abnormal expression of proteins linked to the synthesis of ROS, suggesting the presence of redox dysregulation in these patients (Andrs-Benito et al., 100 toxicity identified from an unbiased genome-wide nonessential yeast gene knockout study revealed dysregulation of mitochondrial and NADPH related metabolic pathways (Chai and Gitler, 2016)