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Similar content being viewed by others Introduction Nephrolithiasis, commonly known as kidney stone disease, is a prevalent and recurrent urological condition with a recurrence rate of up to 50% within the first five years [1, 2]

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Key experimental observations include: Preserved Bone Formation: Rodent models demonstrate maintained periosteal activity and longitudinal growth rates despite controlled dosing, indicating localized skeletal responsiveness without broad endocrine activation

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