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They work indirectly, in short bursts, if at all

In an embodiment, specific saturated C 16 -C 22 fatty acids that are suitable for the compounds and uses thereof disclosed herein include, but are not limited to, hexadecanedioic acid (C 16 diacid), heptadecanedioic acid (C 17 diacid), octadecanedioic acid (Cis diacid), nonadecanedioic acid (C 19 diacid), eicosanedioic acid (C 20 diacid), heneicosanedioic acid (C 21 diacid), docosanedioic acid (C 22 diacid), including branched and substituted derivatives thereof