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March 5, 2013

Compounds 47 and 48 (Figure 6), with IC 50 values of 0.83 and 0.43 M, respectively, which possess aryl-substituted piperazines with acetamide linkers, showed the best activity as DPP-4 inhibitors

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This included autoimmune gastritis, various forms of infectious gastritis, drug-induced gastritis, radiation gastritis, alcohol gastritis, chemical gastritis, gastritis due to duodenal reflux, and gastritis connected with other conditions like sarcoidosis, vasculitis and Crohns disease