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The primary endpoint was the change from baseline in the Movement Disorder SocietyUnified Parkinsons Disease Rating Scale (MDS-UPDRS) Part 3 scores over 12 months

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Strengths and Limitations The strengths of this meta-analysis are related to the incorporation of direct evidence from recently published head to head trials, the variety of outcomes assessed, and the investigation of plausible clauses of heterogeneity by sensitivity analyses