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Semaglutide Overview Semaglutide is a GLP-1 receptor agonist , originally developed to help manage blood sugar levels in patients with type 2 diabetes

This compounded medication is only available when the commercially available product is unavailable or when a prescriber determines that there is a clinically significant difference for the patient

The SUSTAIN 7 RCT demonstrated that once-weekly semaglutide is superior to once-weekly dulaglutide in terms of reductions in HbA1c and bodyweight, both of which are clinically relevant endpoints in a population of patients with T2D, with an NMA in Japanese patients with T2D corroborating these results

Annals of Internal Medicine , 153, 435-441

HDAC6 is activated in the type 2 diabetic mice, the db/db mice, and the podocytes exposed to AGE