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Regular monitoring and realistic expectations are advised, particularly for individuals with chronic conditions, those on medications, or those who are pregnant or breastfeeding

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In STEP 1, investigators randomized about 1900 patients (mean BMI = 38) to either once weekly semaglutide or placebo

Participants were required to have a body mass index (BMI) of 27 kg/m or greater with at least one weight-related comorbidity, or a BMI of 30 kg/m or greater without comorbidities

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