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Western blot (WB) results revealed a significant increase in the expression of Ki-67 and Lamin B, while the protein levels of P21, P16, and -H2AX decreased following FOXO4-DRI treatment (Figure 4A)

Prolonged ER stress leads to the activation of pro-apoptotic signaling (CHOP is a key player) (Hetz, 2012)

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