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Specifically, the UL of 1,000 mg/day of -tocopherol in any supplemental form (equivalent to 1,500 IU/day of RRR --tocopherol or 1,100 IU/day of all - rac --tocopherol) corresponds to the highest dose unlikely to result in hemorrhage in almost all adults (2)

This duality of action for UA complicates the attribution of solely anti or pro-oxidant effects, as an adaptive antioxidant response likely involves UA acting via a primary pro-oxidant pathway