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Literature suggests antioxidant depletion and altered endogenous antioxidant systems precedes OS [12, 13]

doi: 10.3390/su10020391 22 Gngora-CastilloE.Ibarra-LacletteE.Trejo-SaavedraD

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TGF1-induced suppression of glutathione antioxidant defenses in hepatocytes: Caspase-dependent post-translational and caspase-independent transcriptional regulatory mechanisms