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In a study of over 2,500 adults with obesity, people who took 5 mg of Mounjaro for 72 weeks lost an average of 15% of their body weight

Davis J, Fischl AH, Beck J et al (2022) 2022 National standards for diabetes self-management education and support

It belongs to a class of drugs known as GLP-1 receptor agonists, which work by mimicking a natural hormone in the body called glucagon-like peptide-1 (GLP-1)

That number comes from body composition analysis in clinical populations, and it is significantly higher than the lean mass loss associated with moderate caloric restriction alone