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While a causal relationship has not been established, patients with depression or other psychiatric conditions should be monitored for changes in mood or behavior, particularly during the initial weeks of treatment or following dose adjustments

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In general, the higher the EGRac, the less endogenous FAD is available, thus the poorer the blood riboflavin levels 22

For most but not all studies HEK and MDCK cells were serum starved for 24 hours prior to the initiation of drug treatment