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A 2024 randomized controlled trial (RCT) with 60 women (ages 40-65) applied 0.1% GHK-Cu cream twice daily for 12 weeks, yielding 31% wrinkle reduction (visia analysis) and 28% improved skin elasticity versus placebo (Kim et al., 2024)

What has been reported in the available human pilot research is that no significant adverse effects were observed - which is a meaningful data point for safety consideration, even if it does not establish efficacy by clinical standards

The abdomen is usually easiest to inspect and rotate, the outer thigh is another visible option, and the upper arm is harder to use without help

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