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Kyle KA, Willett TL, Baggio LL, Drucker DJ, Grynpas MD

On April 30, 2026, the FDA proposed formally excluding semaglutide and tirzepatide from the 503B bulk drug substances list, a move that would close the last major large-scale compounding pathway for these medications if finalized

In the tiny human trials so far it is well tolerated, but the sample sizes are small and selective (this isnt a good representation of either a)

Appreciating these triumphs builds a mindset that can face obstacles and keep going with renewed enthusiasm

Careful handling protocols ensure reliable and reproducible results within research parameters