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IGF-1 then activates intracellular pathways such as PI3K and mTOR, which regulate protein synthesis
Studies that used 1 mg/day in oral and intravenous trials did not show meaningfully better outcomes than lower doses, and higher doses were associated with more reports of headache, diarrhea, and gastrointestinal effects
In animal studies, Dihexa was found to be approximately 1,000 times more potent than BDNF (brain-derived neurotrophic factor) at promoting synapse formation
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