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Subcutaneous administration of pegbelfermin over 16 weeks was generally well tolerated and significantly decreased hepatic fat fraction based on MRI in MASH subjects during a phase 2 study (NCT02413372)

These findings, which align with previous reports that pharmacologic inhibition and germline knockout of JNK protect against APAP toxicity [27, 28, 36, 39,40,41,42], support a model where diploid hepatocytes resist injury through suppression of JNK-mediated cell death

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Nrgaard CH, Friedrich S, Hansen CT, et al