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This may be related to the reduction of butyric acid-producing members of clostridial cluster, such as Clostridium coccoides and Clostridium leptum , and the abundance of Fecalibacterium prausnitzii and Roseburia intestinalis was significantly associated with severe of UC [149, 150]

(2) The PVDF membrane was placed on the carrier stage of the chemiluminescence imager

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