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They can help determine whether its normal irritation or a sign of something more serious

IKK disturbs insulin signaling through direct phosphorylation of insulin receptor substrate-1 (IRS-1) on serine residues or by phosphorylation of the nuclear factor-B (IB) inhibitor, which dissociates nuclear factor-B (NF-B), allowing this factor to translocate to the nucleus and activate inflammatory genes, such as TNF-, IL-6 and MCP-1 [16,17,18]

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Dichloroacetate and cancer: new home for an orphan drug