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In addition, melatonin inhibits the expression of cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) 75 and limits the production of excessive amounts of prostanoids and leukotrienes and nitric oxide (NO), as well as other mediators of the inflammatory process, such as chemokines and adhesion molecules 73,76 (Fig

Weight fluctuations of 2-3 pounds are normal due to fluid shifts, but sustained weight gain of more than 5 pounds over several weeks suggests an underlying issue

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G., Ding, W