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By tightly regulating methylation capacity and homocysteine levels, the methionine cycle plays a fundamental role in gene regulation, detoxification, and metabolic homeostasis

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Pyridoxine has a history of successful use, at doses ranging from 50 to 800 mg per day, for the prevention and treatment of HFS caused by sorafenib (Nexavar), doxorubicin, 5-FU, docetaxel, or etoposide

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