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Genetic variation in choline-metabolizing enzymes alters choline metabolism in young women consuming choline intakes meeting current recommendations

Epub 2016 Oct 10

317 LncRNAs are involved in the regulation of multiple UC disease-related processes, as shown in Fig

demonstrated that erastin-induced ferroptosis elevated lysosome-associated membrane protein 2a (LAMP2a) expression and promoted chaperone-mediated autophagy (CMA) while facilitating GPX4 degradation, suggesting a possible connection between autophagy and ferroptosis (Wu et al., 2019)

These genetic insights may help provide context for why certain individuals show robust response to triple-agonist therapy while others require dose adjustment or alternative approaches