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When acetaminophen is used in therapeutic doses, most of the drug is metabolized via glucuronidation and sulfation

In Phase 2 trials involving 338 participants across all doses, 88.8% of patients at the 12mg dose successfully completed the 48-week study despite experiencing side effects

Participants were recruited from several sources (ISOQOL, the UK PROMs Network, and outcomes research groups in English-speaking countries) between August-November 2024

When systemic glutathione levels are low, the resulting unchecked oxidative stress acts as a constant irritant to mast cells, keeping them in a hyper-reactive state

While it might be easier to present a more hopeful outlook, the honest version provides better results