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GLP-1 and GIP receptor signaling in beta cellsa review of receptor interactions and co-stimulation

Moreover, IGF-1 nasal spray provides a targeted distribution within the nasal passages, allowing peptides to act either systemically or locally

The STEP 1 trial showed participants losing approximately 6% of body weight by week 12, demonstrating that real-world outcomes match what researchers observed under controlled conditions

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Conclusions This meta-analysis demonstrated that although statistically significant weight reduction persists after GLP-1RAs discontinuation, the clinical significance and durability of this effect are limited