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When to choose the conservative schedule Choose the 6-week schedule if any of these apply to you: Previous strong GI reactions to GLP-1 agonists like semaglutide or tirzepatide History of IBS, GERD, or other chronic digestive conditions BMI under 30 (lower body mass can increase sensitivity to fixed doses) Current use of other medications that affect gastric motility First-time use of any GLP receptor agonist The research is clear on this point

The math is simpler for semaglutide because the doses are larger and easier to measure on standard syringes

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For context, only 4.2% of placebo participants achieved complete pain freedom