The overall incidence of AEs was similar between oral semaglutide and comparators (approximately 6080% of patients in any subgroup had an AE) and, as expected, gastrointestinal AEs (primarily nausea, vomiting and diarrhoea) made up a substantial proportion of the overall events for oral semaglutide
A total of 1,145 patients were included (529 in STEP-HFpEF and 616 in STEP-HFpEF DM) from 129 sites across 18 countries in Asia, Europe, North America, and South America
If you experience persistent or worsening symptoms, dosage adjustments may be required
However, this represents a functional adaptation rather than true anatomical shrinkage and would likely reverse if eating patterns returned to baseline after medication discontinuation
We would recommend aiming to eat around 1,500 kcal per day