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Therefore, the design, discovery, and development of short and long-acting peptide-based GLP-1RAs, including small-molecule agonists are desirable for therapeutic applications beyond T2DM

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Disease microenvironment heterogeneity The inherent heterogeneity of the disease microenvironment represents a central translational barrier to the success of all precision therapies, including GLP-1R-targeted nanotherapies [503]

While stiffness had no effect on MC proliferation in the presence of COL IV and FN, we observed a higher proportion of BrdU-positive iMCs when exposed to stiff COL I-coated substrates, indicating a synergistic effect of COL I and stiffness on MC proliferation (Fig