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The oral-gut axis thus serves as a critical mediator in systemic inflammation and disease progression, with specific microbial taxa offering potential biomarkers for early detection, as seen in oral cancer where Haemophilus parainfluenzae and Rothia mucilaginosa are malignancy-associated (Nayyar et al., 2025)

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Butyrate, a SCFA derived from probiotic metabolism, downregulates the transcription factor RORt in Th17 cells, curtailing IL-17A secretion a key driver of lupus nephritis considerably lowering pro-inflammatory cytokines like TNF- and IL-6 (146) ( Table 2 )

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