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NadA is a surface protein and is involved in adhesion to epithelial cells (Capecchi et al., 2005), brain microvascular endothelial cells (Kulkarni et al., 2020) and binds with high affinity to sialic acid-binding immunoglobulin-type lectins (Siglec)-5 and Siglec-14, promoting bacterial invasion (Benucci et al., 2024)