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Thus, ABCG5 and ABCG8 along with ACAT serve as gate keepers and block the uptake of plant sterols and likely also play an important role in determining the efficiency of cholesterol absorption (humans typically absorb only approximately 50% of dietary cholesterol with a range of 25-75%)

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The company took it through an early safety study in healthy volunteers and then a mid-stage trial in patients with ulcerative colitis, a serious bowel disease