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Thus, we have demonstrated that GSH-targeted therapy selectively kills PC cells in an oxidative stress-dependent manner and that the differences in basal ROS level and antioxidant scavenging capacity induced by stratified expression of VRK2 can well account for the heterogeneous sensitivity to GSH inhibition

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The remaining five patent applications focus on modifications to the indazole substituent in the side chain

In October 2024, the Medicines and Healthcare products Regulatory Agency (MHRA) issued a reminder to healthcare professionals regarding the prescription-only status of GLP-1s, retiring the importance of adverse reporting and the need to remain vigilant to potential misuse 6

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