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Protocol details: Cerebrolysin: 10 ml IV, 5 days per week for 4 weeks Donepezil: 10 mg daily (or current prescribed dose) Assessment: ADAS-cog and CIBIC+ at baseline, week 4, and week 12 Repeat: Cerebrolysin courses every 3 months while maintaining daily donepezil The clinical trial supporting this combination found that the dual approach produced the best cognitive scores at every study visit compared to either monotherapy

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Lifton, R

International Journal of Clinical Pharmacology, Therapy and Toxicology , 1981