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FASN FASN is the central enzyme in DNL, catalyzing the synthesis of PA, a long-chain SFA, from acetyl-CoA and malonyl-CoA as substrates, with NADPH serving as a continuous electron donor

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In 1975, Kligman and Willis described the use of the association of 0.1% tretinoin, 5% HQ, and 0.1% dexamethasone in skin lightening [32]