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Like, we don't know what technology will look like in three years, but you can bet that some of those novel technologies will tap into the very systems that I'm talking about now, and there certainly will be other stressors to come about that will tap into these pathways

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KLF2 regulates eNOS uncoupling via Nrf2/HO-1 in endothelial cells under hypoxia and reoxygenation

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This is called the cell senescence-associated secretory phenotype (SASP factors)

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