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Their primary mechanisms include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner Suppressing glucagon release , which reduces hepatic glucose production Slowing gastric emptying , promoting satiety and reducing appetite Acting on central nervous system pathways involved in appetite regulation These combined effects lead to improved glycaemic control in people with type 2 diabetes and significant weight reduction in those with obesity

It is not clear why Novo Nordisk had so many misgivings about maintaining this very important patent, as the 2019 maintenance fee was only CAD 450

Reduces the appearance of dark spots and pigmentation

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