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Long-term risks include: gallstones chronic gallbladder inflammation need for gallbladder removal (cholecystectomy) recurrent biliary pain Thyroid Tumor Risk (Black Box Warning) Several GLP-1 drugs carry an FDA boxed warning for thyroid C-cell tumors and Medullary Thyroid Carcinoma (MTC), based on long-term rodent studies

SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1/HO-1 pathway based on network pharmacology analysis and experimental validation

The transient nature of side effects is supported by median duration data showing nausea episodes lasting 8 days, diarrhea 3 days, and vomiting 2 days

Treatment with ketone ester also diminished the dependency of CD4 + T cells on glucose but promoted their potential to oxidize amino acids and fatty acids (Extended Data Fig