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A recent study suggested that plasma levels of 5-MT, a compound related to serotonin metabolism, may be decreased in CFS patients, but this has been interpreted as a confounder caused by serotonin-selective reuptake inhibitor (SSRI) use in these patients (40)

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And, indeed, when you put all the observational studies together, we find there is no signicant correlation between the levels of B12 in the blood and lung cancer, whether or not you smoked

It also means that the dose-response curve is steeper, which reinforces why accurate calculation and gradual escalation are non-negotiable

"Glycine metabolism in animals and humans: implications for nutrition and health." Amino Acids, vol