Some people may experience: Acne outbreaks Skin redness Itching or rash 2
Hydroxocobalamin, the form most commonly used in the UK, may cause: Injection site reactions (pain, redness, or swelling) Temporary reddish discolouration of urine Rarely, hypersensitivity reactions Very rarely, hypokalaemia in severely deficient patients when treatment is initiated (potassium levels should be monitored in severe deficiency) B12 injections are considered very safe, with no upper tolerable limit established, as excess B12 is excreted in urine
It helps create digestive enzymes and delivers nutrients to and from our cells
The published preclinical work (Neelakantan et al., referenced via PMC5826726) reported clean safety at 20 mg/kg subcutaneous in mice over 11 days
Researchers found that those in the treatment group had a greater decrease in kidney function and an increase in vascular events, including heart attack and stroke