glp 1 obesity GLP-1 Weight Regain Is Not a Flaw. It's Proof Is a Chronic Disease GLP-1-based therapies for diabetes, obesity

The Annals of pharmacotherapy , 46 (2), 240247

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As a dual-action peptide, it targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, enhancing its efficacy

Proteases rapidly degrade many peptides, exhibit poor oral bioavailability due to enzymatic breakdown in the digestive tract, and suffer from short systemic half-lives, reducing their clinical efficacy