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Sci Total Environ
Each experimental treatment group included 10 mice
Cognitive function sharper
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Weight reduction with type 2 diabetes: In REDEFINE 2 the combination produced about 15.7% mean weight loss versus placebo over 68 weeks in adults with T2D [2]
Key findings include: Upregulation of Shh pathway components in ischemic brain regions Enhanced neural stem cell proliferation and differentiation Improved angiogenesis supporting tissue repair Modulation of blood-brain barrier integrity The Shh pathway activation appears particularly relevant in stroke recovery models, where enhanced neurogenesis and vascular support correlate with functional improvements
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