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TB-500 (TB-4) component Two Phase 2 dermal ulcer trials referenced in the Goldstein review (PMID 22074294) reported acceleration of healing without serious adverse events at the studied subcutaneous doses

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Maggi GC, Lomanto B, and Mazzola, C

These findings suggest that Epitalon may help coordinate pineal-hypothalamic-endocrine signaling networks, potentially contributing to circadian rhythm regulation and broader neuroendocrine homeostasis in experimental models