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For instance, dysregulated miR-93-3p targets the PI3K/AKT signaling pathway, disrupting granulosa cell proliferation and apoptosis and ultimately arresting follicular development ( Above all, Epigenetic dysregulation in PCOSincluding DNA methylation, histone modifications, and non-coding RNA alterationsdisrupts ovarian function, hormone balance, and insulin signaling, contributing to hyperandrogenism, metabolic dysfunction, and impaired folliculogenesis

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doi: 10.1097/00003246-200104000-00036

Buse JB, Vilsbll T, Thurman J, Blevins TC, Langbakke IH, Bttcher SG, et al