164,165,166 Breach of blood-brain barrier results in the infiltration of blood-borne cells (erythrocytes, leucocytes, macrophages, and platelets) and molecules (such as fibrin, fibrinogen, collagen, or albumin)
Oxidative stress occurs when there are too many damaging free radicals in the body compared to beneficial antioxidants, meaning the body cannot neutralize them
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Such disruption includes mutations in methyl-CpG-binding protein 2 ( MeCP2 ), 104,105 activity-dependent neuroprotective protein ( ADNP ), 106 engrailed 2 ( EN2 ), 107 voltage-dependent calcium channel subunit 1C ( CACNA1C ), 108 T-box brain 1 ( TBR1 ), 109,110 myocyte enhancer factor 2C ( MEF2C ) 111 and de novo deletions or duplications in 15q11-q13 (which cover ubiquitin-protein ligase E3A ( UBE3A ))
Detox help is another role it may play