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8 To date, no patients with primary systemic carnitine deficiency have been identified

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Some patients focus on weight reduction, while others focus on diabetes prevention, cardiovascular health, or improved mobility

These different results could be accounted for by both the expression of NADPH oxidase induced by KRAS G12D overexpression, which leads to ROS generation, and an increase in NRF2-dependent ROS scavenging in cells expressing physiological levels of KRAS G12D