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I think of this as more of a relief than a burden, Salas-Whalen says

Inhibition of lipid oxidation increases glucose metabolism and enhances 2-deoxy-2-[(18)F]fluoro-D-glucose uptake in prostate cancer mouse xenografts

Researchers have linked this to increased metabolic rate at the cellular level, driven by the downstream effects of NNMT inhibition on how fat cells process and expend energy