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thaliana GSH2 is the target of several redox PTMs that could impact its activity and thus modulate glutathione biosynthesis, i.e., sulfenylation (Wei et al., 2020) and nitrosylation (Figure 3 and Supplementary Table 4

These findings suggest that cell death in GSH-depleted cells happens through ferroptosis and autophagy

Genome scale metabolic modeling of cancer

Importantly, glutathione can cross the blood-brain barrier , providing neuroprotection and cognitive clarity benefits unavailable from most other antioxidants

The similarities and discrepancies between these studies and ours can be attributed to the following factors: (1) Population differences: The populations in the referenced studies were primarily from the Mediterranean region of Turkey and southern China, while the participants in this study were from eastern China