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The research protocol of this study was approved by the institutional review boards of Tohoku University Graduate School of Medicine (20221847, 20231283) and the institutions mentioned above
For participants receiving 40 mg daily of oral semaglutide, three different dose-titration protocols were used where patients were titrated up to the full 40 mg dose in 6 weeks (fast dose escalation), 12 weeks (standard dose escalation), or 24 weeks (slow dose escalation)
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