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Beyond histone tails, the p300/CBP complex can also acetylate lysine residues of other proteins among which there are both Nrf2 and the p65 subunit of NF-B [27]

June 30, 2025

1 In the absence of adequate GSH concentrations, numerous oxidative and nitrosative reactive intermediates persist, including superoxide, hydroxide, peroxide, and peroxynitrite radicals, which all can lead to modification of cellular macromolecules including lipid membranes (measured in vivo by F2-isoprostanes) and DNA adduct formation (measured in vivo by 8-hydroxy-2-deoxyguanosine [8-OHdG])

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This has a number of harmful consequences and puts people at risk for heart, kidney, eye, and brain disease including heart attack, peripheral arterial disease, stroke, loss of vision, and kidney failure