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Redness and swelling may occur, and the area may be painful for a few hours

In the B16F10 melanoma model, directing anti-CTLA4 and anti-PD-1 treatment to the TDLN reduces the risk of immune-related adverse events, reduces distant metastases and recurrence, and enhances the anti-cancer T cell repertoire (233)

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As seen in Figure 5, DEM administration severely depleted mucosal GSH by 1 hour to levels similar to those of TNBS+ethanol-treated rats