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J Endocrinol Investig 19:433440 Muoz MT, Barrios V, Pozo J, Argente J (1996) Insulin-like growth factor I, its binding proteins 1 and 3, and growth hormone-binding protein in children and adolescents with insulin-dependent diabetes mellitus: clinical implications

After treatment, a temporary increase in pain and inflammation is expected for a few days as part of the healing cascade