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Loss of Nrf2 also increased the sensitivity of mice to myelin oligodendrocyte glycoprotein (MOG 3555)-stimulated autoimmune attack on myelin and oligodendrocytes in the central nervous system that causes autoimmune encephalomyelitis, an experimental model of multiple sclerosis (91)

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Unfavorable environmental conditions result in the formation of reactive oxygen species (ROS) in different subcellular compartments, which may intracellularly activate anti-oxidants (e.g., key player GSH) and defense responses leading to plant acclimation